
Spicy, smoky, and deeply satisfying, this skillet catfish is the kind of weeknight dinner that feels indulgent without working against your health goals. A homemade Cajun spice blend — built from smoked paprika, garlic powder, oregano, thyme, and a hit of cayenne — coats each fillet in bold flavor while keeping the ingredient list clean and free of the added sugars and inflammatory fillers that sneak into store-bought seasoning packets. Catfish is a lean, protein-rich fish that supports stable blood sugar and satiety, both of which matter when you're managing hormonal balance through diet. Cooking it in extra virgin olive oil adds a dose of healthy monounsaturated fat, which pairs beautifully with the anti-inflammatory herbs in the spice blend. The cast iron skillet does the heavy lifting here, creating a gorgeous golden crust without any breading or refined carbs. A squeeze of fresh lemon at the end brightens everything up and makes the whole dish feel restaurant-worthy. It's the kind of recipe that proves eating with your hormones in mind doesn't have to mean bland or boring.
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In a small bowl, combine the smoked paprika, garlic powder, onion powder, dried oregano, dried thyme, black pepper, cayenne, and kosher salt. Stir until evenly mixed.
Pat the catfish fillets dry with paper towels, then sprinkle the spice blend evenly over both sides of each fillet, pressing gently so it adheres.
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